Table 4.
Treatment | Gastric cancer cell line | ||||
rAd-p53 (vp/mL) | OXA (μg/mL) | SGC-7901 | BGC-823 | HGC-27 | |
OXA | 0 | 3.2 | 12.32 ± 0.8ea | 11.21 ± 1.05ea | 8.86 ± 1.01ea |
rAd-p53 | 5 × 106 | 0 | 7.89 ± 1.13ca | 6.07 ± 0.97ca | 4.32 ± 1.03ca |
5 × 107 | 0 | 10.03 ± 1.03ca | 8.38 ± 1.04ca | 6.03 ± 0.99ca | |
5 × 108 | 0 | 12.34 ± 1.05ca | 10.52 ± 0.89ca | 8.31 ± 1.02ca | |
5 × 109 | 0 | 15.04 ± 1.03ca | 11.34 ± 0.55ca | 10.12 ± 1.01ca | |
rAd-p53 + OXA | 5 × 106 | 3.2 | 22.05 ± 1.01eca | 15.67 ± 1.03eca | 13.48 ± 1.01eca |
5 × 107 | 3.2 | 25.13 ± 1.06eca | 18.83 ± 1.02eca | 15.32 ± 1.07eca | |
5 × 108 | 3.2 | 27.24 ± 1.73eca | 21.07 ± 1.01eca | 18.93 ± 1.06eca | |
5 × 109 | 3.2 | 35.67 ± 1.03eca | 26.16 ± 1.05eca | 22.34 ± 1.13eca | |
Control | 0 | 0 | 1.32 ± 1.02 | 1.29 ± 0.97 | 1.27 ± 0.68 |
P < 0.05 vs control;
P < 0.05, rAd-p53 vs rAd-p53 + oxaliplatin (OXA) with the same dose of rAd-p53;
P < 0.05, OXA vs rAd-p53 + OXA with the same dose of OXA.