Table 5.
Treatment | Gastric cancer cell line | ||||
rAd-p53 (vp/mL) | OXA (μg/mL) | SGC-7901 | BGC-823 | HGC-27 | |
OXA | 0 | 3.2 | 33.52 ± 1.6ea | 23.28 ± 1.35ea | 18.72 ± 1.61ea |
rAd-p53 | 5 × 106 | 0 | 7.89 ± 1.13ca | 6.51 ± 0.97ca | 4.07 ± 0.83ca |
5 × 107 | 0 | 12.47 ± 1.43ca | 8.78 ± 1.34ca | 6.43 ± 0.79ca | |
5 × 108 | 0 | 21.84 ± 1.05ca | 14.24 ± 0.89ca | 11.72 ± 1.12ca | |
5 × 109 | 0 | 36.73 ± 1.03ca | 28.64 ± 1.75ca | 21.82 ± 1.81ca | |
rAd-p53 + OXA | 5 × 106 | 3.2 | 42.38 ± 1.51eca | 35.72 ± 1.13eca | 28.84 ± 1.21eca |
5 × 107 | 3.2 | 54.84 ± 1.26eca | 48.63 ± 1.62eca | 34.51 ± 1.47eca | |
5 × 108 | 3.2 | 58.41 ± 1.13eca | 51.71 ± 1.41eca | 38.5 ± 1.16eca | |
5 × 109 | 3.2 | 63.91 ± 1.23eca | 55.73 ± 1.35eca | 42.92 ± 1.33eca | |
Control | 0 | 0 | 4.67 ± 1.32 | 1.74 ± 0.67 | 1.15 ± 0.58 |
P < 0.05 vs control;
P < 0.05, rAd-p53 vs rAd-p53 + oxaliplatin (OXA) with the same dose of rAd-p53;
P < 0.05, OXA vs rAd-p53 + OXA at the same dose of OXA.