FIG. 7.

Influence of RecA modification on metronidazole sensitivity. H. pylori wild-type strain P1, the isogenic recA (P33), eno, and hp158 mutants, and P33 complemented with wild-type RecA (pDH38) or with RecA (T189M) (pWS127) were assayed for metronidazole sensitivity with an E-test. Due to variations between individual experiments, results were calculated as ratios of MICs for the mutants in comparison to those for the wild-type for each experiment. The MIC for the P1 wild-type strain was on average 0.25 μg/ml. All results are expressed as means of the results from at least three independent experiments. *, The MIC for strain P33 was 0.016 μg/ml in only one of five experiments, otherwise it was <0.016 μg/ml.