Table 3.

Genetic score (GS) sensitivities and specificities with their 95% CIs by sex estimated in the exploratory sample

Genetic score threshold	Males		Females
	Sensitivity (95% CI)	Specificity (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)
3	1.00	0.000	-	-
4	1.00 (0.99 to 1.00)	0.01 (0.01 to 0.02)	1.00	0.00
5	0.97 (0.94 to 1.00)	0.03 (0.02 to 0.05)	1.00	0.00
6	0.90 (0.85 to 0.94)	0.19 (0.15 to 0.22)	1.00	0.00
7	0.75 (0.70 to 0.80)	0.41 (0.36 to 0.46)	1.00	0.00
8	0.47 (0.43 to 0.52)	0.64 (0.59 to 0.69)	0.99 (0.98 to 1.00)	0.10 (0.00 to 0.19)
9	0.24 (0.19 to 0.28)	0.86 (0.82 to 0.90)	0.90 (0.85 to 0.96)	0.20 (0.15 to 0.25)
10	0.08 (0.06 to 0.11)	0.95 (0.92 to 0.97)	0.78 (0.71 to 0.85)	0.40 (0.31 to 0.49)
11	0.02 (0.01 to 0.04)	0.98 (0.96 to 0.99)	0.61 (0.52 to 0.69)	0.65 (0.57 to 0.74)
12	0.00	1.00	0.37 (0.29 to 0.44)	0.86 (0.80 to 0.92)
13	-	-	0.17 (0.11 to 0.23)	0.94 (0.89 to 0.98)
14	-	-	0.03 (0.01 to 0.06)	0.99 (0.97 to 1.00)

The two GSs chosen as threshold value to define children with a higher risk of autism in males and in females are shown in bold.