FIG. 4.

Histopathology. Half an hour after stroke, wedge shaped edematous lesion consisted of pallor and vacuolation of neuropils at low magnification, high-magnification view revealed dark neurons (A-C). Between 6-12 hours, eosinophilic neurons appeared, which showed swelling of cytoplasm (D, E). The swollen cytoplasm of eosinophilic neurons was positive for NF immunostainning (F). After one day, neutrophil infiltration was shown at the edges of the infarct, and continued to 2 days (G, H). Between 3-7 days, the infarct lesion was characterized by central necrosis surrounded by macrophages and newly formed capillaries (I, J). At 2-4 weeks, cortical necrosis was completely resolved and the lesion was replaced by gliosis and fibrosis (K, L).