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. 2011 Sep 23;18(12):1815–1824. doi: 10.1038/cdd.2011.120

Table 1. Available p53 animal models.

Species Name Modulation of p53 isoforms Ref.
Drosophila   Overexpression of DΔNp53 in cells 45
    Overexpression of transgenic DΔNp53 under the control of tissue-specific promoters 47,49,50,51,52,53
    Overexpression of transgenic dominant-negative mutant DΔNp53 53,54
    Inactivation of Dp53 locus 49,53
       
Zebrafish Tg(Δ113p53:gfp) Overexpression of transgenic ZΔ113p53-GFP morpholino (Δ113p53-MO) 61
    Overexpression of ectopic ZΔNp53 59
       
Mouse MΔ41p53/MΔ41p53 wt/MΔ41p53 Overexpression of transgenic MΔ41p53 65
       
  MΔ122p53/MΔ122p53 wt/MΔ122p53 Overexpression of transgenic MΔ122p53 68
  m/m wt/m ‘m'=deletion of exon 1–6 69