Table 2. Role of p53 isoforms in human cancers.

Cancer	Isoform	Observation	Ref.
Breast cancer	Δ133p53α	Overexpression	33
	p53β	Loss of expression	33,78
	p53γ	Loss of expression Prognosis of mutp53/p53γ as good as wtp53	33,79
Acute myeloid leukaemia	p53β/γ	Increased expression in response to chemotherapy	78
Ovarian cancer	p53β	Serous and poorly differentiated tumours/worse recurrence-free and overall survival	77
	Δ40p53	Improved recurrence-free survival	74
Li–Fraumeni syndrome	Δ40p53	G-quadruplex structure overlapping TP53 PIN3/early age at first cancer diagnosis in patients carrying A1A1 compared with patients carrying A1A2	72