Table 4.

Clinical manifestations of patients with TGIF alterations (including probands and mutation or deletion-positive relatives)

Clinical feature	Patients (n = 25) with intragenic TGIF mutations n (%)	Patients (n = 18) with TGIF deletions n (%)	p valuea
Microcephaly	10 (40)	9(50)	0.5496
Hypotelorism	9(36)	3(17)	0.1911
Cleft lip and/or palate	9(36)	7(39)	0.8994
Midface hypoplasia	8(32)	7(39)	0.7497
Single maxillary central incisor	2(8)	6(33)	0.0517
Hypopituitarism	4(16)	5(28)	0.4554
Extra-neuronal/craniofacial findings	0	6(33)	0.0030*
Total	25	18	N/A

^*Significant; N/A = not applicable.

^aBy 2-tailed Fisher's exact test or χ² when appropriate.