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. Author manuscript; available in PMC: 2012 Nov 10.
Published in final edited form as: J Med Chem. 2011 Oct 12;54(21):7567–7578. doi: 10.1021/jm200920s

Figure 5. The structural and functional relationships among the matriptase activation inhibitors.

Figure 5

The chemical structures of the four matriptase activation inhibitors are presented and compared in relation to their IC50 values. Some of the analogs which showed no inhibition of matriptase activation (without measurable IC50 values) are also presented and compared in order to show the negative impact of the modifications in the surrounding rings (R1, R2 and R3) on the inhibitory activity. The arrows indicate a decreasing in inhibition potency with the structure changes.