. Author manuscript; available in PMC: 2012 Aug 1.

Published in final edited form as: Immunotherapy. 2011 Oct;3(10):1223–1233. doi: 10.2217/imt.11.100

Table 1. Receptor–ligand pairs of selectins, chemokines and integrins involved with CD8 T-cell traffcking.

Receptor	Ligand
*Selectin*	*Selectin ligands*
L-selectin (CD62L)	PNAd
P-selectin (CD62P)	PSGL-1
E-selectin (CD62E)	CD43, CD44, ESL-1, PSGL-1
*Chemokine receptor*	*Chemokine*
CCR7	CCL19, CCL21
CCR5	CCL5
CCR10	CCL27, CCL28
CCR9	CCL25
CCR4	CCL17
CXCR3	CXCL9, CXCL10
*Integrin*	*Integrin ligand*
VLA-1 (α₁β₁)	Collagen, laminin
VLA-4 (α₄β1)	VCAM-1, fbronectin
LFA-1 (α_Lβ₂)	ICAM-1
α ₄ β ₇	MAdCAM-1
α _E β ₇	E-cadherin

ESL E-selectin ligand; LFA: Lymphocyte function-associated antigen; MAdCAM: Mucousal addressin cell adhesion molecule; PNAd: Peripheral node addressin; PSGL P-selectin glycoprotein ligand; VLA: Very-late antigen.