TABLE 3.

Mutations associated with reduced susceptibility to nelfinavir^a

Isolates with mutation						Mean FC
Mutation	No. of isolates	% Isolates withb:		ORc	P valued	Mutant	Wild type	P valuee
		High FC	Low FC
L10I	214	14.4	6.5	2.2	<0.0001	1.47	1.15	<0.0001
L10V	77	6.2	2.2	2.8	0.0002	1.46	1.17	0.0014
R57K	402	20.6	12.9	1.6	0.0004	1.33	1.15	<0.0001
D60E	210	13.7	6.4	2.1	<0.0001	1.52	1.15	<0.0001
Q61N	31	2.6	0.9	3.0	0.0120	1.55	1.17	0.0016
I62V	695	34.6	22.5	1.5	<0.0001	1.34	1.14	<0.0001
A71T	181	16.0	5.0	3.2	<0.0001	1.66	1.15	<0.0001
A71V	64	6.2	1.7	3.6	<0.0001	1.72	1.16	<0.0001
T74S	21	2.0	0.6	3.4	0.0174	1.79	1.17	0.0002
V77I	899	51.0	28.4	1.8	<0.0001	1.37	1.09	<0.0001
I93L	816	49.7	25.4	2.0	<0.0001	1.39	1.10	<0.0001

^aMutations for which P was <0.05 by the Fisher exact test and ORs >1.5 are listed. Reduced susceptibility to nelfinavir was considered an FC >2.0.

^bA high FC was >2.0, and a low FC was <2.0.

^cOR is the ratio of the percentage of isolates with the mutation for which the FC was high to the percentage of isolates with the mutation for which the FC was low.

^dThe P value was determined by the Fisher exact test; mixtures with wild-type and mutant viruses were counted as mutants.

^eThe P value was determined by the unpaired comparison of means test; mixtures were excluded.