Table 4.
Relationship between plasma HDL-cholesterol, macrophage reverse cholesterol transport and atherosclerosis in response to genetic manipulation in mice
| Genetic manipulation | Tissue | Effect on plasma HDL-C | Effect on macrophage RCT | Effect on atherosclerosis |
|---|---|---|---|---|
| ApoA-I overexpression | Liver | Increase | Increase | Decrease |
| ApoA-I knockout | Whole body | Decrease | Decrease | Increase |
| SR-BI overexpression | Liver | Decrease | Increase | Decrease |
| SR-BI knockout | Whole body | Increase | Decrease | Increase |
| CETP expression | Liver | Decrease | Increase | Decrease |
| LCAT overexpression | Liver | Increase | Decrease | Increase |
| LCAT + CETP expression | Liver | Variable | Neutral | Neutral |
| LCAT knockout | Whole body | Decrease | Neutral | Variable |
| ABCA1 knockout | Macrophage | No change | Decrease | Increase |
| ABCG1 knockout | Macrophage | No change | Decrease | Decrease |
| ABCA1 + ABCG1 knockout | Macrophage | No change | Decrease | Increase |
| SR-BI knockout | Macrophage | No change | Neutral | Variable |
ABCA1, ATP-binding cassette transporter A1; CETP, cholesteryl ester transfer protein; HDL-C, HDL-cholesterol; LCAT, lecithin-cholesterol acyltransferase; RCT, reverse cholesterol transport; SR-BI, scavenger receptor class B type 1. Table adapted from [85•].