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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Oct 5;21(23):6973–6976. doi: 10.1016/j.bmcl.2011.09.123

Scheme 3.

Scheme 3

Reagents and conditions: (a) HCl, 80 °C, 1 h; (b) i: BnONH2, MeOH, reflux, 1 h; ii: NaBH3CN, MeOH, HCl, rt, 1 h; (c) AcCl, TEA, CH2Cl2, rt, 18 h; (d) i: TMSBr, CH2Cl2, 0 °C, 30 min; ii: H2O, rt, 18 h; (e) RBr or RCl, TEA, DMF or DMPU, 60 °C, 6 h; (f) H2, 10% Pd/C, MeOH.