Table 2.

Baseline Characteristics of Patients in the High, Intermediate and Low CRS7 Risk Groups

	CRS7 Risk Group(N = 938)						p-value
	High, >0.7 (n= 440)		Intermediate, 0.5–0.7 (n= 310)		Low, <0.5 (n= 188)
	Mean/%	SD	Mean/%	SD	Mean/%	SD
Demographics
Age, y	49.6	7.0	50.3	7.4	50.9	6.8	0.02*
Gender, Male	72.3%	-	68.7%	-	70.2%	-	0.46§
Race/ethnicity		-		-
African-American	19.6%	-	20.0%	-	9.0%
Caucasian	68.6	-	68.1%	-	87.2%		<0.00
Hispanic and Other	11.8	-	11.9%	-	3.7%	-	1‡
Source of randomization		-		-			0.53‡
Lead-in	62.7%	-	65.2%	-	61.2%	-
Express	22.3%	-	21.9%	-	23.4%	-
Breakthrough	3.6%	-	3.2%	-	2.7%	-
Relapser	11.4%	-	9.7%	-	12.8%	-
Treatment assignment				-
Peginterferon	47.7%	-	49.4%	-	53.2%	-	0.22§
Control	52.3%	-	50.6%	-	46.8%	-
Body Mass Index (BMI)	29.9	5.6	30.1	5.2	30.1	5.5	0.46*
Viral Factors
Log10 HCV RNA, IU/mL	6.45	0.50	6.39	0.55	6.40	0.55	0.19*
Duration of infection, y	28.3	8.1	27.9	8.1	28.2	7.7	0.81*
Laboratory Values
Hemoglobin, g/dL	15.0	1.4	14.9	1.5	15.0	1.3	0.50*
White blood cells, x1000/mm3	5.82	1.98	5.69	1.80	5.85	1.80	0.99*
Platelets, x1000/mm3	165.5	67.0	163.7	65.6	162.3	60.1	0.70*
Albumin, g/dL	3.85	0.39	3.83	0.39	3.93	0.41	0.09*
AST, U/L	83.4	55.4	94.9	61.9	83.4	51.3	0.28*
ALT, U/L	102.2	77.9	115.1	81.5	101.7	63.9	0.35*
Alkaline Phosphatase, U/L	100.4	42.3	104.0	48.4	92.7	46.5	0.03*
Total bilirubin, mg/dL	0.79	0.40	0.81	0.41	0.78	0.42	0.82*
Prothrombin time, INR	1.04	0.10	1.04	0.11	1.04	0.12	0.98*
AFP, ng/mL	15.9	22.0	18.1	27.9	19.2	40.0	0.39*
Liver histology
Ishak fibrosis score		-		-		-
5 or 6	42.5%	-	40.6%	-	38.3%	-	0.32§
<5	57.5%	-	59.4%	-	61.7%	-
Esophageal varices on EGD	26.2%	-	25.9%	-	25.1%	-	0.80§
CRS7	0.80	0.06	0.60	0.04	0.35	0.10	-

^*Kendall’s Tau-b Correlation Test,

^§Cochran-Armitage Trend Test,

^‡Cochran-Mantel-Haenszel Mean Score Test. All p-values are derived from two-sided tests.