Table 2.

Examples of lncRNAs in cancer

lncRNA	Function	Cancer Type	Cancer Phenotype	Molecular Interactors	Reference
HULC	Biomarker	Hepatocellular	Not known	Unknown	10
PCA3	Biomarker	Prostate	Not known	Unknown	82, 83
ANRIL/p15AS	Oncogenic	Prostate, Leukemia	Suppression of senescence via INK4A	Binds PRC1 and PRC2	46-48, 68
HOTAIR	Oncogenic	Breast, hepatocellular	Promotes metastasis	Binds PRC2 and LSD1	28, 55, 56
MALAT1/NEAT2	Oncogenic	Lung, prostate, breast, colon	Unclear	Contributory to nuclear paraspeckle function	76-79
PCAT-1	Oncogenic	Prostate	Promotes cell proliferation; inhibits BRCA2	Unknown	9
PCGEM1	Oncogenic	Prostate	Inhibits apoptosis; promotes cell proliferation	Unknown	7, 10
TUC338	Oncogenic	Hepatocellular	Promotes cell proliferation and colony formation	Unknown	19
uc.73a	Oncogenic	Leukemia	Inhibits apoptosis; promotes cell proliferation	Unknown	18
H19	Oncogenic; Tumor suppressive	Breast, hepatocellular	Promotes cell growth and proliferation; activated by cMYC; downregulated by prolonged cell proliferation	Unknown	30, 34-36
GAS5	Tumor suppressive	Breast	Induces apoptosis and growth arrest; Prevents GR-induced gene expression	Binds GR	57, 58
linc-p21	Tumor suppressive	Mouse models of lung, sarcoma, lymphoma	Mediates p53 signaling; induces apoptosis	Binds hnRNP-k	73
MEG3	Tumor suppressive	Meningioma, hepatocellular, leukemia, pituitary tumors	Mediates p53 signaling; inhibits cell proliferation	Unknown	69-72
PTENP1	Tumor suppressive	Prostate, colon	Binds PTEN-suppressing miRNAs	Unknown	81

Abbreviations: Polycomb Repressive Complex 1, PRC1; Polycomb Repressive Complex 2, PRC2; Glucocorticoid Receptor, GR