TABLE 1.

Effects of S-3578 and cefepime on viable counts in lung tissues of mice infected with S. pneumoniae

Total daily dose (mg/kg)	No. of times of administration (day)	Viable cells in infected tissues (log CFU/lungs)
		S-3578	Cefepime
240	1	4.33 ± 0.93	4.56 ± 0.87
	2	3.39 ± 0.73	3.93 ± 0.28
	4	1.19 ± 0.32a	1.90 ± 0.71a
	8	1.49 ± 0.63a	1.10 ± 0.17a
80	1	4.20 ± 0.65	4.48 ± 0.45
	2	3.46 ± 0.29	4.05 ± 0.35
	4	2.33 ± 0.57a	2.87 ± 0.76a
	8	1.54 ± 0.49a	1.94 ± 0.41a
24	1	4.82 ± 0.38	5.00 ± 0.20
	2	4.48 ± 0.45	4.21 ± 0.40b
	4	2.84 ± 0.71a	3.70 ± 0.39b
	8	1.45 ± 0.48c	3.13 ± 0.48c
8.0	1	5.04 ± 0.42	4.90 ± 0.47
	2	4.31 ± 0.58	4.61 ± 0.22
	4	3.68 ± 0.52b	4.41 ± 0.32
	8	3.59 ± 0.85b	4.48 ± 0.84
2.4	1	4.88 ± 0.12	5.29 ± 0.52
	2	4.98 ± 0.70	5.02 ± 0.40
	4	4.51 ± 0.64	5.20 ± 0.60
	8	4.76 ± 0.51	5.38 ± 0.58
0		5.34 ± 0.17	5.34 ± 0.30

^aP < 0.01 compared with administration one and two times daily with the same total daily dosage.

^bP < 0.01 compared with administration once daily.

^cP < 0.01 compared with administration one, two, and four times daily with the same total daily dosage.