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Selectivity of the phenyl-thiazolylurea-sulfonamides
| Compound | IC50 (μM)a
|
||
|---|---|---|---|
| E. coli Phe-RS | Mammalian cytoplasmic Phe-RS | Human mitochondrial Phe-RS | |
| 1 | 0.007 | >200 | 60 |
| 2 | 0.008 | >200 | >200 |
| 3 | 0.015 | >200 | >200 |
| 4 | 0.015 | >200 | 25 |
| 5 | 0.025 | >200 | 10 |
| 6 | 0.02 | >200 | 90 |
| 7 | <0.005 | >200 | 90 |
Values shown indicate concentrations of 50% inhibition of E. coli Phe-RS compared to those of inhibition of mammalian cytoplasmic Phe-RS (rabbit reticulocyte lysate) and human mitochondrial Phe-RS.
