Table 1.
Demographic and Risk Factors By HPV-16 Status
| Variables | HPV-16negative | HPV-16positive | p-value |
|---|---|---|---|
| Gender | |||
| Male | 30 (76.9) | 18 (90.0) | 0.222 |
| Female | 9 (23.1) | 2 (10.0) | |
| Age | |||
| <50yr | 10 (25.6) | 7 (35.0) | 0.621 |
| 50–64yr | 22 (56.4) | 11 (55.0) | |
| ≥65yr | 7 (18.0) | 2 (10.0) | |
| Race | |||
| Caucasian | 27 (69.2) | 20 (100.0) | 0.021 |
| African American | 10 (25.7) | 0 (0.0) | |
| Other | 2 (5.1) | 0 (0.0) | |
| Smoking status | |||
| Never | 12 (30.8) | 7 (35.0) | 0.257 |
| Former | 6 (15.4) | 7 (35.0) | |
| Current | 17 (43.6) | 5 (25.0) | |
| Unknown | 4 (10.2) | 1 (5.0) | |
| Drinking status | |||
| Never | 8 (20.5) | 2 (10.0) | 0.585 |
| Former | 4 (10.3) | 1 (5.0) | |
| Current | 19 (48.7) | 13 (65.0) | |
| Unknown | 8 (20.5) | 4 (20.0) | |
| Stage | |||
| Early (I–II) | 17 (44.7) | 1 (5.26) | 0.003 |
| Advanced (III–IV) | 21 (55.3) | 18 (94.74) | |
| TNM | |||
| Tumor | |||
| 1 | 16 (42.1) | 7 (36.84) | 0.574 |
| 2 | 11 (28.9) | 7 (36.84) | |
| 3 | 8 (21.1) | 5 (26.32) | |
| 4 | 3 (7.9) | 0 (0.0) | |
| Lymph Node | |||
| N− | 22 (56.4) | 2 (10.0) | 0.001 |
| N+ | 17 (43.6) | 18 (90.0) | |
| Tumor Site | |||
| Oropharynx | 4 (10.2) | 19 (95.0) | <0.001 |
| Oral cavity | 23 (59.0) | 0 | |
| Larynx | 9 (23.1) | 0 | |
| Hypopharynx | 2 (5.1) | 0 | |
| Unknown primary | 1 (2.6) | 1 (5.0) | |