Table 1.
Distribution of HIF-1α, PHD2/3 expressions studied by double immunostaining methods in formalin/parrafin sections of surgical biopsies from oropharyngeal SCC cases.
| HIF-1α positive cases | |||||
|---|---|---|---|---|---|
| Number of cases | Histology | HIF-1α | PHD2 | PHD3 | Difference in PHD2 and/or 3 expression between HIF-1α positive and negative tumor cells |
| 1 | 1 PD | 2 m-s/10 | s/100 | m/30 | no difference |
| 2 | WD | w-s/20 | s/100 | m/30 | PHD3 is lower |
| 3 | WD | s/20 | m/100 | m/30 | no difference |
| 4 | PD | s/10 | s/100 | m-s/90 | PHD3 is lower |
| 5 | WD | m-s/80 | w/100 | s/10 | PHD3 is lower |
| 6 | PD | s/30 | w/100 | m-s/80 | no difference |
|
| |||||
| HIF-1α negative cases | |||||
|
| |||||
| 7 | WD | nd | w/100 | m-s/40 | |
| 8 | WD | nd | w-m/100 | m-s/40 | |
| 9 | WD | nd | w/100 | m-s/80 | |
| 10 | PD | nd | s/100 | m-s/10 | |
| 11 | PD | nd | s/100 | s/70 | |
| 12 | WD | nd | m-s/100 | m-s/50 | |
| 13 | PD | nd | s/100 | s/100 | |
| 14 | WD | nd | w-m/100 | m-s/30 | |
| 15 | PD | nd | m-s/100 | s/40 | |
1
PD: poorly differentiated WD: well differentiated
2
Immunostaining: s:strong, m:moderate, w:weak, nd:not detectable
Numbers after the symbols indicate the estimated percentage of immunostained tumor cells.