TABLE 2.
Cytokine release profiles of FZ- and L-AMB-treated THP-1 monocyte culturesa
| Cytokine | Array locationb | Relative level in L-AMB cultures at 6 hc | Fold increase in level in FZ-treated cultures at 6 hd |
|---|---|---|---|
| IL-6 | E3-4d | − | ∼28 |
| IL-8 | G3-4 | H | 13 |
| IL-10 | H3-4 | − | ∼2 |
| GRO | G1-2 | VL | 8.9 |
| MCP-1 | D5-6 | H | 3.8 |
| RANTES | H5-6 | L | NC |
| TNF-α | B7-8 | VL | 102 |
THP-1 cells were cultured for 6 h with either L-AMB or FZ (5 μg/ml).
See Fig. 2 for the locations of the duplicate spots in the matrix.
Relative levels: −, undetectable; H, high; L, low; VL, very low.
When the cytokine level in L-AMB cultures was essentially zero, the “∼” symbol was used to indicate an approximation; NC, no change (less than or equal to twofold difference).