TABLE 1.

Relative fluoroquinolone susceptibilities of 32 ofloxacin-resistant M. tuberculosis isolates exhibiting seven gyrA mutation types^a

Strain	Amino acid change	MIC (mg/liter)
		Moxifloxacin	Gatifloxacin	Sitafloxacin	Ofloxacin	Levofloxacin	Sparfloxacin
ATCC 25177	None	0.25	0.25	0.25	0.25	0.25	0.06
ATCC 27294		0.25	0.25	0.25	0.25	0.25	0.06
M5	Ala90→Val	1	1	0.5	8	4	2
M22		1	1	0.5	8	4	2
M93		2	1	0.5	16	8	2
FCK		2	2	1	4	2	0.5
G53211		1	1	0.5	4	2	1
SC1	Ser91→Pro	1	2	1	4	2	0.5
SC14		1	2	1	2	1	0.25
469		2	4	>4	4	2	0.5
484		4	4	4	4	2	0.5
M13	Asp94→Gly	2	2	1	16	>8	4
M29		4	2	1	16	8	4
M38		2	4	2	16	>8	>8
M70		2	4	2	>16	>8	>8
M83		4	4	2	>16	>8	4
M88		2	4	2	16	8	4
M96		8	4	4	>16	>8	>8
C855		1	2	1	4	2	0.5
SC15		2	2	1	8	2	1
Y777		4	4	2	8	4	1
TB72		1	4	1	8	4	0.5
M44	Asp94→His	2	4	2	16	8	>8
M46		2	4	2	16	8	4
M97		2	2	1	16	8	4
M3	Asp94→Tyr	2	2	4	16	8	2
M28		2	2	1	16	8	2
M47		2	4	4	>16	>8	>8
M69		1	2	1	16	8	>8
M86		2	2	2	16	8	4
M59	Asp94→Ala	2	2	0.5	8	4	2
M62		1	2	0.5	8	4	2
M68		1	1	0.5	8	4	2
TB392	Asp94→Asn	2	4	4	8	4	2

^aThe Ser95→The substitution is not listed.