Table 2.

Distinctive Functional Enrichments of the Low- and High-CpG O/E Genes.

GO Biological Process Term	Expected		Observed	Significance
Low-CpG O/E genes
Cellular macromolecule metabolic process		575.1	678	1.0 × 10−10
RNA processing		98.7	146	1.2 × 10−9
Translation		97.3	138	2.7 × 10−7
Gene expression		375.7	448	4.0 × 10−7
Cellular protein metabolic process		285.4	349	7.1 × 10−7
mRNA metabolic process		81.3	115	4.5 × 10−6
Macromolecule metabolic process		659.3	737	5.6 × 10−6
mRNA processing		75.6	107	1.1 × 10−5
Cellular metabolic process		786.4	864	1.2 × 10−5
High-CpG O/E genes
System development		191.6	304	5.2 × 10−22
Multicellular organismal development		237.8	350	7.2 × 10−19
Organ development		147.7	241	1.1 × 10−18
Transcription factor activity		49.5	105	2.9 × 10−17
Anatomical structure development		235.7	341	7.9 × 10−17
Developmental process		267.4	376	1.7 × 10−16
Signal transducer activity		57.7	115	3.7 × 10−16
Signaling		173.5	261	8.3 × 10−15
Sequence-specific DNA binding		30.5	71	1.0 × 10−14