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SV2A in the human bowel. SV2A-immunoreactive fibers (arrowed) in control human colonic biopsies (A), irritable bowel syndrome (B), inflammatory bowel disease without pain (C) and inflammatory bowel disease with pain (D), arrowheads indicate villi, magnification 40× and image analysis of SV2A-immunoreactive fibers in control IBS and quiescent IBD with (+P) and without pain (−P). Mean ± standard error of the mean of the percent area is shown (E).
Note: *P = 0.023.
