Table 1.

Cochrane risperidone reviews

Review	Sample/studies	For risperidone	Against risperidone
Rattehalli et al9 Risperidone vs placebo for schizophrenia	n = 1363, 10 RCTs	Greater reduction in PANNS/BPRS scores Less number of risperidone subjects left the trial owing to lack of efficacy	More EPSE but did not reach statistical significance Prolactin elevation
Hunter et al11 Risperidone vs typical antipsychotic medication for schizophrenia	n = 2368, 9 RCTs	Better outcomes in both short and long term trials Reduction in relapse rate Less extrapyramidal side effects	Weight gain Prolactin elevation and sexual side effects were comparable to haloperidol
Komossa et al14 Risperidone vs other atypical antipsychotics	n = 7760, 45 RCTs	Better PANNS score reduction than quetiapine and ziprasidone Better than ziprasidone in leaving study due to inefficacy Equal efficacy compared to aripiprazole and amisulpride	Olanzapine better on PANNS reduction Olanzapine and clozapine better than risperidone in leaving study due to inefficacy EPSE Prolactin elevation

Abbreviations: RCT, randomized controlled trial; PANNS, positive and negative syndrome scale; BPRS, brief psychiatric scale; EPSE, extra pyramidal side effects.