TABLE 1.
Substitutions in AF-CYP51A resulting in azole resistance in A. fumigatus isolates
| Isolate | MIC (μg/ml)
|
Substitution in AF-CYP51A | ||
|---|---|---|---|---|
| POS | ITZ | VOR | ||
| ND158a | 0.03 | 0.12 | 0.25 | None (parental strain of MS6, R4-1, and R7-1) |
| MS6a | 0.5 | >16 | 0.12 | Gly54Arg |
| R4-1a | 1 | >16 | 0.25 | Gly54Glu |
| R7-1a | 4 | >16 | 0.25 | Gly54Trp |
| F55064b | 0.25 | 0.25 | 0.25 | None (parental strain of F10 and F33) |
| F10b | 0.25 | 2 | 16 | Gly138Arg |
| F33b | 0.25 | 0.5 | 8 | Gly448Ser |
a
MICs and data on mutations from Mann et al. (13).
b
MICs from a personal communication from E. Manavathu; data on mutations as published (Manavathu et. al., 41st ICAAC).