TABLE 3.
Variations in bacterial resistance rates during a before-and-after intervention trial that replaced CEP with piperacillin-tazobactam
| Organism/phenotypic resistancea | Resistance rate (%)b
|
Pc | |
|---|---|---|---|
| Period 1 (baseline) | Period 2 (intervention) | ||
| E. coli/CEP | 11.5 (157) | 8.3 (96) | NS |
| K. pneumoniae/CEP | 68.4 (38) | 37.5 (40) | 0.012 |
| P. mirabilis/CEP | 57.9 (38) | 29.4 (51) | 0.013 |
| P. aeruginosa/CEP | 5.7 (35) | 6.2 (32) | NS |
| P. aeruginosa/TZP | 11.4 (35) | 6.2 (32) | NS |
| Acinetobacter species/TZP | 21.7 (23) | 23.1 (26) | NS |
| S. aureus/MET | 35.56 (107) | 36.8 (68) | NS |
a
TZP, piperacillin-tazobactam; MET, methicillin.
b
See program design in the text for details. Values in parentheses indicate the total number of strains.
c
That is, for period 1 versus period 2. NS, not significant.