FIG. 4.

Antiviral properties of members of two classes of iminosugar derivatives. The antiviral effect of N7-oxadecyl-DNJ (squares) and N7-oxanonyl-6deoxy-DGJ (triangles) on the replication of cp BVDV was evaluated by yield assay as described in detail in Materials and Methods. Monolayers of MDBK cells were infected at an MOI of 0.1 and treated with increasing drug concentrations. After 2 days, plaques were counted by eye under the microscope. The percent replication relative to that of untreated infected cells is represented as a function of the drug concentration used. The mean value of three independent experiments is shown. Antiviral features obtained with the ncp BVDV strain were identical (data not shown).