TABLE 1.
Antiviral features of the two long-alkyl-chain iminosugar derivatives used in this studya
| Compound | IC50 (μM) at MOI:
|
IC90 (μM) at MOI:
|
Cytotoxic concn (μM)
|
SI50 (CC50/IC50) at MOI:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.01 | 0.1 | 1 | 0.01 | 0.1 | 1 | 10% | 30% | 50% | 0.01 | 0.1 | 1 | |
| N7-oxadecyl-DNJ | 17.5 ± 2.5 | 35 ± 5 | 80 ± 20 | 62.5 | 200 ± 20 | 1,000 ± 200 | >1,000 | >2,000 | >5,000 | >250 | >125 | >50 |
| N7-oxanonyl-6deoxy-DGJ | 2.5 ± 0.5 | 17.5 ± 2.5 | 125 ± 25 | 7.5 ± 2.5 | nr | nr | >3,000 | >3,500 | >4,000 | >1,333.33 | >200 | >26.66 |
a
Values indicated are the means of numbers obtained in at least three sets of experiments ± the standard deviation. nr, not reached. Cytotoxic concentrations were obtained as described in Materials and Methods.