Figure 2.

Anti-β₂ integrin mAb and anti-CXCR3 mAb suppress eosinophil adhesion enhanced by ICAM-1 and IP-10. (A) IP-10-enhanced eosinophil adhesion to ICAM-1 is inhibited by anti-β₂ integrin mAb. Eosinophils were pre-incubated with either anti-integrin mAb (3 μg/ml) or control IgG for 15 min prior to analysis of adhesion in the presence or absence of IP-10. Data are shown as means ± SEM of 6 experiments using cells from different donors. (B) IP-10-enhanced eosinophil adhesion to ICAM-1 is inhibited by anti-CXCR3 mAb. Eosinophils were pre-incubated with either anti-CXCR3 mAb (3 μg/ml) or control IgG for 15 min prior to analysis of adhesion in the presence or absence of IP-10. Data are shown as means ± SEM of six experiments using cells from different donors. Open and filled bars, eosinophil adhesion without and with IP-10, respectively. **P < 0.01 versus without IP-10. ^##P < 0.01, ^###P < 0.001 versus mouse IgG1.