Table 1.

Production of cytokines and chemokines by eosinophils stimulated with CXCR3 ligands.

Cytokine	Control (pg/ml)	IP-10 (pg/ml)	Mig (pg/ml)	I-TAC (pg/ml)
IL-1ra	1.8 ± 0.7	25.0 ± 2.1*	3.8 ± 1.3	3.9 ± 0.9
IL-1β	0.3 ± 0.1	6.5 ± 2.5*	2.6 ± 1.0	1.8 ± 0.9
IL-2	0.0 ± 0.0	2.0 ± 0.1*	0.1 ± 0.1	0.1 ± 0.0
IL-4	0.1 ± 0.0	1.1 ± 0.1*	0.1 ± 0.0	0.1 ± 0.0
IL-5	0.0 ± 0.0	0.3 ± 0.1*	0.0 ± 0.0	0.0 ± 0.0
IL-6	9.2 ± 4.9	80.5 ± 27.4*	40.5 ± 17.4	29.5 ± 14.8
IL-7	0.1 ± 0.0	0.9 ± 0.1*	0.2 ± 0.1	0.2 ± 0.0
IL-8	186.8 ± 89.8	404.7 ± 73.3*	315.3 ± 79.7	251.7 ± 76.5
IL-9	1.1 ± 0.2	4.4 ± 0.4*	1.8 ± 0.3	2.2 ± 0.3*
IL-10	0.7 ± 0.2	2.1 ± 0.4*	1.2 ± 0.4	1.7 ± 0.6
IL-12(p70)	0.3 ± 0.1	0.9 ± 0.1*	0.4 ± 0.1	0.3 ± 0.1
IL-13	1.1 ± 0.3	1.8 ± 0.2*	1.4 ± 0.2	1.4 ± 0.2
IL-15	0.2 ± 0.0	0.5 ± 0.1*	0.3 ± 0.1	0.3 ± 0.1
IL-17	0.8 ± 0.2	2.5 ± 0.7*	0.6 ± 0.2	0.7 ± 0.4
Eotaxin	1.7 ± 0.6	23.2 ± 0.5*	2.4 ± 1.1	2.4 ± 0.9
FGF	1.4 ± 0.5	5.6 ± 1.3*	1.1 ± 0.6	3.1 ± 1.1
G-CSF	0.2 ± 0.1	2.5 ± 0.4*	0.5 ± 0.2	0.3 ± 0.2
GM-CSF	0.8 ± 0.3	9.4 ± 1.0*	1.6 ± 0.4	1.7 ± 0.5
IFN-γ	2.6 ± 0.6	107.0 ± 10.3*	5.4 ± 2.1	5.6 ± 2.0
MCP-1	32.6 ± 14.3	86.5 ± 28.7*	65.5 ± 24.6	53.5 ± 22.1
MIP-1α	6.4 ± 2.8	30.7 ± 10.4*	17.8 ± 8.9	14.5 ± 7.9
MIP-1β	93.7 ± 31.0	183.5 ± 19.1*	160.0 ± 24.5*	135.5 ± 25.7
PDGF	0.6 ± 0.3	2.2 ± 0.5*	0.4 ± 0.1	1.2 ± 0.3
RANTES	6.5 ± 0.9	20.3 ± 1.0*	7.8 ± 1.1	7.9 ± 1.0
TNF-α	4.0 ± 1.9	19.2 ± 4.5*	5.3 ± 3.3	2.7 ± 1.0
VEGF	7.8 ± 2.6	13.3 ± 2.5*	10.5 ± 3.3	10.4 ± 2.8

Eosinophils were incubated with CXCR3 ligands for 24 h, and the concentrations of cytokines and chemokines in cell-free supernatants were measured using Bio-plex assay kits. *P < 0.05 versus without CXCR3 ligands.