TABLE 2.

Lethality of murine skin infection by various ΔcsrRS GAS strains or strain combinations

Strain	Toxin phenotype		n	No. dead at 48 h (%)	P (Fisher exact test)
	SLS	SpeB			vs strain RS	vs RSA+RSB
RS	+	+	12	12 (100)		0.012
RSA	−	+	17	0	<10−9	0.0002
RSB	+	−	17	5 (29)	0.0003	0.11
RSA+RSB	1/2	1/2	19	11 (58)	0.012
RSA+RSAB	−	1/2	6	0	0.00005	0.02
RSB+RSAB	1/2	−	6	1 (17)	0.0007	0.16
RSAB	−	−	4	0	0.0006	0.09