Table 2.

Analysis of the human host-flavivirus protein-protein interaction network

Nb of targeting viruses	Nb of targeted human proteins	Targeted human proteins
4	2 (1.7%)	APBB1IP, ENO1
3	10 (8.3%)	ARID2, AZI2, CAMTA2, CEP63, MLPH, MYH9, NME3, TAF15, TRAF4, VPS11
2	26 (21.7%)	ARNTL, BCL2L14, CCDC99, CEP250, DNTTIP2, FAM184A, GGA1, GRN, JAG1, LAMB2, NFKBIA, OPTN, PABPC1, PDE4DIP, PHC2, PHLDB3, PIAS3, RNF125, RNUXA, SCRIB, SNRPA, TOM1L1, TRIM21, TXNDC9, VIM, ZBTB17
1	82 (68.3%)	-

We determined the number of flavivirus species that interact with each cellular host protein found to be targeted by NS3 or NS5 (Y2H plus literature).