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. 2011 Nov 14;6(11):e27352. doi: 10.1371/journal.pone.0027352

Figure 6. Sensitivity to drug-induced apoptosis in young and aged fibroblasts, hESCs, young-iPSCs, and aged-iPSCs.

Figure 6

(A) Apoptotic cell death was measured both at the basal level and upon the treatment with two different doses of actinomycin D (AM) (10−9 M and 10−7 M). Pictures were taken after 24 h and 48 h. Scale bars, 100 µm. (B) Induction of apoptosis after 24 h AM treatment in young and aged-derived fibroblasts. (C) Apoptosis levels after 48 h AM treatment in young and aged-derived fibroblasts. (D) Apoptotic cell death at 24 h in hESCs, young-iPSCs (iPS2, iPS4, iB4, iB5) and aged-iPSCs (OiPS3, OiPS6, OiPS8, OiPS16). (E) Induction of apoptosis after 48 h AM treatment in pluripotent stem cells.