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. 2011 Nov 14;6(11):e25006. doi: 10.1371/journal.pone.0025006

Table 1. Intraindividual variability of bile acids and C4.

Analyte ConcMin ConcMax Subject A Values <LOQ Subject B Values <LOQ Subject C Values <LOQ Subject D Values <LOQ
CA <0.020–0.049 0.077–4.48 0.599±149% 1/24 0.372±155% 0/24 0.039±51% 5/24 0.828±154% 0/24
UDCA <0.020 0.048–0.138 0.033±89% 10/24 0.009±147% 21/24 0.024±69% 11/24 0.037±106% 13/24
CDCA 0.039–0.163 0.641–2.41 0.489±129% 0/24 0.507±105% 0/24 0.322±31% 0/24 0.535±120% 0/24
DCA 0.271–0.480 0.770–2.96 0.983±63% 0/24 0.628±41% 0/24 0.488±22% 0/24 0.934±54% 0/24
LCA <0.050–0.281 0.102–0.799 0.434±29% 0/24 0.350±48% 0/24 0.047±51% 14/24 0.234±43% 0/24
GCA 0.030–0.162 2.00–2.67 0.726±93% 0/24 0.788±55% 0/24 0.618±92% 0/24 0.733±73% 0/24
GUDCA 0.014–0.029 0.186–0.311 0.093±83% 0/24 0.077±48% 0/24 0.111±73% 0/24 0.088±48% 0/24
GCDCA 0.150–0.497 3.82–7.42 1.90±73% 0/24 2.34±47% 0/24 2.25±84% 0/24 1.53±52% 0/24
GDCA 0.080–0.415 2.01–5.61 1.75±77% 0/24 0.879±50% 0/24 0.976±91% 0/24 0.902±63% 0/24
GLCA <0.050 <0.050–0.444 0.021±22% 24/24 0.164±63% 3/24 0.036±67% 18/24 0.059±72% 11/24
TCA <0.005–0.015 0.136–0.700 0.108±167% 0/24 0.059±53% 0/24 0.168±95% 0/24 0.043±157% 2/24
TUDCA <0.002 0.003–0.031 0.004±105% 8/24 0.001±70% 22/24 0.007±104% 5/24 0.002±122% 20/24
TCDCA 0.019–0.033 0.377–2.25 0.356±103% 0/24 0.183±58% 0/24 0.563±98% 0/24 0.112±89% 0/24
TDCA 0.010–0.022 0.161–1.88 0.235±190% 0/24 0.076±52% 0/24 0.432±107% 0/24 0.079±116% 0/24
TLCA <0.005–0.005 0.031–0.069 0.021±62% 0/24 0.027±50% 0/24 0.015±66% 3/24 0.009±76% 7/24
C4 <0.005–0.016 0.038–0.135 0.014±72% 5/24 0.058±64% 0/24 0.034±51% 0/24 0.038±42% 0/24
Primary BAs 0.456–1.13 8.23–13.2 4.18±62% - 4.25±43% - 3.96±81% - 3.78±54% -
Secondary BAs 0.768–1.41 4.00–9.32 3.57±56% - 2.21±34% - 2.14±70% - 2.34±37% -
Unconjugated BAs 0.598–0.940 1.63–8.46 2.54±79% - 1.87±65% - 0.920±23% - 2.57±92% -
Conjugated BAs 0.386–1.03 10.2–18.6 5.21±85% - 4.59±49% - 5.18±89% - 3.56±62% -
Total BAs 1.22–2.55 12.2–20.7 7.75±59% - 6.46±38% - 6.10±77% - 6.13±46% -

Minimal and maximal concentrations and mean±variation coefficient are given for the 15 individual bile acids, C4 and the grouped bile acids for all four subjects. Concentrations are given in [µmol/L] and intraindividual variability is given as the mean concentration [µmol/L]±CV [%].