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. 2011 Nov 14;6(11):e27686. doi: 10.1371/journal.pone.0027686

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Llorens-Martin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Dominant negative GSK3β K85 (DN- GSK3β) transfection reduces the percentage of motile mitochondria (F_1,16 = 16.794; p = 0.001). B: Number of anterograde movements after DN-GSK3β transfection is increased compared to pcDNA3-transfected neurons (F_1,16 = 10.085; p = 0.007). C: Number of retrograde movements after DN-GSK3β transfection is decreased compared to that of pcDNA3-transfected neurons (F_1,17 = 32.054; p = 0.001). D–E: Absence of GSK3β activity modifies the average anterograde (F_1,18 = 5.297; p = 0.034) but not the retrograde run length. F–G: The lack of GSK3β activity decreases the velocity of anterograde mitochondrial trafficking (F) (F_1,17 = 4.257; p = 0.048) whereas it does not modify the speed of individual retrograde movements (G). H: The number of mitochondria per length unit remains unchanged after DN-GSK3β transfection. Asterisk: * 0.05>p≥0.01; ** 0.01>p≥0.001.