Table 5.
Multivariable regression analysis for neurodevelopmental impairment, Mental Developmental Index < 70, and Psychomotor Developmental Index < 70. Cytokine were averaged among samples from days 0–4 and then log-transformed due to skewness.
| Neurodevelopmental Impairment | ||||
|---|---|---|---|---|
| OR | CI | p value | Significant covariates | |
| IL-1β | 0.92 | 0.80 – 1.06 | 0.27 | Race, gender, birth weight |
| IL-8 | 1.17 | 1.00 – 1.37 | 0.049 | Gender, birth weight |
| TNF-α | 0.85 | 0.72 – 1.01 | 0.07 | Race, gender, birth weight |
| RANTES | 0.97 | 0.78 – 1.21 | 0.79 | Race, gender, birth weight |
| IL-2 | 1.08 | 0.92 – 1.28 | 0.34 | Race, gender, birth weight |
| Mental Developmental Index < 70 | ||||
|---|---|---|---|---|
| OR | CI | p value | Significant covariates | |
| IL-1β | 0.89 | 0.79 – 1.01 | 0.08 | Race, gender, birth weight |
| IL-8 | 1.16 | 0.98 – 1.36 | 0.08 | Race, gender, birth weight |
| TNF-α | 0.84 | 0.71 – 0.98 | 0.03 | Race, gender, birth weight |
| RANTES | 0.98 | 0.78 – 1.23 | 0.84 | Race, gender, birth weight |
| IL-2 | 1.05 | 0.89 – 1.24 | 0.58 | Race, gender, birth weight |
| Psychomotor Developmental Index < 70 | ||||
|---|---|---|---|---|
| OR | CI | p value | Significant covariates | |
| IL-1β | 0.94 | 0.79 – 1.12 | 0.48 | Gender, birth weight |
| IL-8 | 1.21 | 1.00 – 1.46 | 0.047 | Gender, birth weight |
| TNF-α | 0.90 | 0.73 – 1.11 | 0.32 | Gender, birth weight |
| RANTES | 0.94 | 0.71 – 1.23 | 0.63 | Gender, birth weight |
| IL-2 | 0.99 | 0.81 – 1.21 | 0.91 | Gender, birth weight |