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. Author manuscript; available in PMC: 2012 Nov 18.
Published in final edited form as: J Proteomics. 2011 Aug 22;74(12):2745–2759. doi: 10.1016/j.jprot.2011.08.009

Figure 5.

Figure 5

Identification and quantitative comparison of the peptide DYM*DTLPPTVGDDVGK from cleavage and polyadenylation specificity factor subunit 6 (CPSF6). (A) MS/MS spectrum of the 18O-labeled version of this peptide. (B) MS spectra of the doubly charged peptide pairs showing the relative abundance of this peptide as a result of forward (left) and reverse (right) 18O-labeling. Consistent abundance ratios between the forward (18O/16O=0.63) and reverse (16O/18O=0.70) labeling indicate down-regulation of CPSF6 in the mouse lymph nodes due to DeGussa P25 TiO2 nanoparticle treatment. * indicates the oxidized methionine residue in the peptide.