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. Author manuscript; available in PMC: 2012 Nov 16.
Published in final edited form as: FEBS Lett. 2011 Oct 19;585(22):3555–3559. doi: 10.1016/j.febslet.2011.10.020

Fig. 5.

Fig. 5

L213R attenuates inhibition of KATP by sulfonylureas. (A) L213R KATP currents indicating their reduced response to the normally (tightly) binding, slowly dissociating, insulin secretagogue glibenclamide (Glb). Electrophysiological conditions are like in Fig. 4. The vertical arrow marks patch excision in the intracellular solution. (B) The steady-state inhibition of L213R vs WT KATP by tolbutamide (Tlb) under conditions indicated; n = 10 for each bar.