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Simulation of INa and IKs. Simulations of the sodium (INa, Panel A) and potassium (IKs, Panel B) currents were conducted using the Iyer, Mazhari and Winslow model. Resultant currents were obtained at a stimulation frequency of 2.8 Hz in control (wild type) and in the A341V mutant (A341V+KCNQ1+KCNE1). A progressive decrease in INa amplitude accompanied by a depressed IKs current with slower activation kinetics was observed in the A341V mutant compared to the control.
