. Author manuscript; available in PMC: 2012 Dec 1.

Published in final edited form as: Biochim Biophys Acta. 2011 Aug 10;1810(12):1285–1293. doi: 10.1016/j.bbagen.2011.07.018

Table 1. Biophysical Variables of Wild Type IKs (KCNQ1+KCNE1) and A341V Constructs.

	KCNQ1+KCNE1	A341V+KCNE1	A341V[GFP]+KCNE1	A341V+2KCNE1
V_0.5, mV	35.6 ± 0.9	46.2 ± 0.9^*	40.4 ± 1.3	41.4 ± 0.7
k	16.3 ± 0.8	9.0± 0.8^*	7.2 ± 0.9	5.9 ± 0.7
T_0.5, ms	447 ± 76	1172 ± 72^*	1231 ± 69	980 ± 90
τ_f, ms	215 ± 15	142 ± 21 ^†	163 ± 9	117 ± 5
τ_s, ms	2357 ± 465	564 ± 74 ^*	760 ± 90	628 ± 67
n	8	11	7	11

V_0.5 = voltage of half-maximal activation; k = slope factor; T_0.5 = activation time to half-maximal amplitude at +60 mV; τ_f = fast time constant; τ_s = slow time constant; n = number of experiments

V_0.5, k, T_0.5, τ_f and τ_s were determined as described in Methods. Data are presented as mean ± SE.

P < 0.01 versus KCNQ1+KCNE1,

^†

P < 0.05 versus KCNQ1+KCNE1