. Author manuscript; available in PMC: 2012 Dec 1.

Published in final edited form as: Biochim Biophys Acta. 2011 Aug 10;1810(12):1285–1293. doi: 10.1016/j.bbagen.2011.07.018

Table 2. Biophysical Variables of A341V Constructs: Heterozygous Clinical Situation (A341V+KCNQ1+KCNE1) and Corresponding Wild Type IKs (2KCNQ1+KCNE1).

	A341V+KCNQ1+KCNE1	2KCNQ1+KCNE1
V_0.5, mV	30.2 ± 1.2 ^*	23.3 ± 1.7
k	12.2 ± 0.5 ^†	14.6 ± 0.7
T_0.5, ms	514 ± 55 ^*	263 ± 30
τ_f, ms	197 ± 9	219 ± 19
τ_s, ms	729 ± 74 ^*	2095 ± 239
n	12	11

V_0.5 = voltage of half-maximal activation; k = slope factor; T_0.5 = activation time to half-maximal amplitude at +60 mV; τ_f = fast time constant; τ_s = slow time constant; n = number of experiments

V_0.5, k, T_0.5, τ_f and τ_s were determined as described in Methods. Data are presented as mean ± SE.

P < 0.01 versus 2KCNQ1+KCNE1,

^†

P < 0.05 versus 2KCNQ1+KCNE1