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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: Dev Cell. 2011 Oct 13;21(5):862–873. doi: 10.1016/j.devcel.2011.09.003

Figure 2. Structures of LRP6(3-4) and Dkk1_C.

Figure 2

(A) The LRP6(3-4) structure, viewed down the pseudo-six fold symmetry axis of propeller 3 (top) or towards the side (bottom). Blades are numbered in repeat 3, and individual strands are labeled in blade 1.

(B) Closeup of the repeat 3-4 interface. Interacting side chains are shown in stick representation. Polar interactions are shown with dashed lines. Repeat 4 residue labels are underlined. The complete list of interactions is given in Table S2. See also Figure S1.

(C) Ribbon representation of Dkk1_C. Disulfide bridges are show in green. The loop between β-strands 5 and 6 is disordered. See also Figure S2

(D) Superposition of human Dkk1_C structure (gold) with the NMR solution structure of mouse Dkk2_C (blue) (PDB entry 2JTK).