Table 2.

RANK (TNFRSF11A) SNPs associated with pQCT outcomes

SNP	Allele	MAF (%)	Type	Skeletal site	Phenotype	Adjusted for center		Adjusted for center, age, weight, and height		Associations with other bone phenotypes in EMAS [15]a
						β (95% CI)	P	β (95% CI)	P
rs9962159	A>G	27.5	Intronic	Distal radius	Total vBMD	−8.33 (−16.29 to −0.38)	0.041	−8.55 (−16.16 to −0.93)	0.028	–
rs12956925	G>A	16.7	Intronic	Distal radius	Trabecular vBMD	−6.79 (−13.22 to −0.36)	0.039	−7.58 (−14.01 to −1.15)	0.021	–
rs9951012	G>A	20.8	Intronic	Distal radius	Cross-sectional area	−9.28 (−17.87 to −0.69)	0.035	−10.23 (−18. 42 to −2.03)	0.015	–
rs4524035	A>G	14.3	Intronic	Distal radius	Trabecular vBMD	−8.59 (−16.30 to −0.87)	0.030	−8.35 (−16.09 to −0.60)	0.035	–
rs8083511	A>C	20.1	Intronic	Distal radius	Cross-sectional area	10.39 (2.05 to 18.73)	0.015	8.90 (0.92 to 16.88)	0.029	–
rs12959396	T>G	47.1	Intronic	Mid-shaft radius	Cortical thickness	0.05 (0.00 to 0.10)	0.046	0.06 (0.01 to 0.10)	0.026	–
				Mid-shaft radius	Medullary area	−2.31 (−4.36 to −0.26)	0.028	−1.87 (−3.85 to 0.12)	0.065	–
rs6567276	T>C	44.2	Intronic	Distal radius	Cross-sectional area	−7.50 (−14.35 to −0.65)	0.032	−8.42 (−14.97 to −1.87)	0.012	PINP ↑, CTX-I ↑
rs17665435	T>A	32.3	3′ downstream	Distal radius	Cross-sectional area	7.44 (0.52 to 14.36)	0.036	8.21 (1.58 to 14.83)	0.015	PINP ↓, CTX-I ↓

β the change in the mean of the outcome variable (in units e.g. mg/mm³) for each copy of the minor allele, CI confidence interval, EMAS European Male Ageing Study, PINP N-terminal propeptide of procollagen I, CTX-I C-terminal cross-linked telopeptide of collagen type I, ↑ the SNP was associated with higher levels of the outcome, ↓ the SNP was associated with lower levels of the outcome

^aOutcomes shown in bold were also significantly associated with the SNP in the subpopulation with pQCT