Table 1.
Brain regions showing significant changes in regional cerebral blood flow in conditioned rats compared to controls
| Brain region | Left | Right |
|---|---|---|
| Cerebral cortex | ||
| Cingulate, dorsal (Cg1, homologous to human anterior cingulate and dorsal part of midcingulate, ACC, MCC, respectively) | + | |
| Cingulate, ventral (Cg2, homologous to ventral part of human midcingulate, MCC) | + | + |
| Insular, anterior (anteriorINS) | + | + |
| Motor, primary (M1) | + | + |
| Prelimbic (PrL, homologous to part of human prefrontal cortex, PFC) | +* | +* |
| Retrosplenial (RS, homologous to human posterior cingulate, PCC) | + | + |
| Somatosensory, primary (S1) | + | +** |
| Somatosensory, secondary (S2) | + | + |
| Entorhinal (Ent) | -* | |
| Subcortical regions | ||
| Amygdala (AMYG), including basolateral (BLA) amygdalopiriform transition area (APir) cortical nuclei (PMCo, PLCo) | + | +* |
| Caudate putamen, anterior dorsal (adCPu) | + | + |
| Caudate putamen, lateral (lCPu) | +** | +** |
| Cerebellum, hemisphere (CbHemis) | +** | +** |
| Cerebellum, vermis (CbVermis) | +* | +* |
| Corpus callosum, forceps minor (fmi) | +* | +* |
| External capsule (ec) | +* | +* |
| Hippocampus, dorsal (dHPC) | + | +* |
| Lateral septal nucleus (LS) | + | + |
| Nucleus accumbens (NAcc) | +* | +* |
| Periaqueductal gray, dorsomedial (DMPAG) | +* | +* |
| Inferior colliculus (IC) | -* | - |
| Pontine nuclei (Pn) | - | - |
Significant increases or decreases in regional blood flow are noted with ‘+’ and ‘-’, respectively, for the left and right hemispheres. Significance is shown at the voxel level (P < 0.05) with extent threshold of 100 contiguous voxels.
Significant at the voxel level P < 0.01.
Significant at the voxel level P < 0.001.
Shaded cells depict regions that showed changes in rCBF in response to acute colorectal distension (CRD) as we previously reported, with the difference that amygdalar activations during acute CRD were noted in the central and lateral nuclei, and changes in the lateral CPu and PAG showed a decrease rather than increase in rCBF [81].