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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2011 Aug 10;96(1-4):76–83. doi: 10.1016/j.prostaglandins.2011.08.001

Figure 2. A dual sEH/COX-2 inhibitor efficiently blocks pain.

Figure 2

A potent dual sEH/COX-2 inhibitor significantly alleviates intraplantar LPS induced allodynia measured by a von Frey mechanical nociception test (n=6 per group). The sEHI and co-administration of celecoxib and sEHI also attenuate the allodynia but not as effectively. Doses of celecoxib (CLX), sEHI (t-AUCB), or the dual inhibitor (10 mg/kg each s.c.) were compared to a combination of CLX + t-AUCB and an LPS control. The sEHI and combination treatment were significantly anti-allodynic when compared to the LPS control (P=0.02 and P<0.001 respectively). However the sEH/COX-2 dual inhibitor significantly (P<0.001) attenuated allodynia at both time points and was more effective than celecoxib or sEHI alone and the combination. Results are presented as percent of baseline mechanical withdrawal threshold on the y-axis.