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. Author manuscript; available in PMC: 2012 Oct 28.
Published in final edited form as: Cell. 2011 Oct 28;147(3):509–524. doi: 10.1016/j.cell.2011.10.009

FIGURE 4. Working model of molecular mechanisms mediating fear memory reconsolidation.

FIGURE 4

All lines are hypothetical. Molecules and processes in green are known to be involved in the initiation of reconsolidation. Molecules and process in black are known to be involved in reconsolidation of fear conditioning. Purple labels denote molecules or elements whose role is not established for fear conditioning, but are part of an established intracellular signaling pathway. AC, adenyl cyclase; AKAP, A-kinase anchoring protein; Arc, activity-regulated cytoskeletal-associated protein; β-AR, Beta Adrenergic Receptor; BDNF, brain derived neurotrophic factor; Ca2+, Calcium; CREB, cAMP Response Element (CRE) binding protein; Egr-1, Early Growth Response Protein 1; MAPK, Mitogen Activated Protein Kinase; mTOR Mammalian Target of Rapamycin; NMDA-R, N-methyl-d-aspartate Glutamate Receptor; Npas4, Neuronal PAS domain protein 4; RNA, Ribonucleic Acid.