Table 2.
Mutations found in EGFR exons 18 to 21
| Exon | Frequency | Mutation type | Heredity | K-ras status |
|---|---|---|---|---|
| TTG to TCG (L707S) n2120 Ti | s | wt | ||
| ACT to GCT (T710A) n2128 Ti | s | wt | ||
| 18 | 5/188 (2.6%) | GAA to GTT (E711V) n2132/2133 Tv | s | wt |
| TTC to TCC (F712S) n2135 Ti | s | wt | ||
| ACG to ACA (T725T) n2175 Ti | g | wt | ||
| 19 | 1/221 (0.5%) | GTC to GTT (V742V) n2226 Ti | g | wt |
| TTC to TCC (F795S) n2384 Ti | s | wt | ||
| 20 | 2/227 (0.8%) | GGC to AGC (G796S) n2386 Ti | g | Wt |
| CGC to CGT (R836R) n2508 Ti | g | M (13) | ||
| CGC to CGT (R836R) n2508 Ti | g | wt | ||
| CGC to CGT (R836R) n2508 Ti | g | wt | ||
| CGC to CGT (R836R) n2508 Ti | g | wt | ||
| 21 | 9/236 (3.8%) | CGC to CGT (R836R) n2508 Ti | g | wt |
| CGC to CGT (R836R) n2508 Ti | g | wt | ||
| CGC to CGT (R836R) n2508 Ti | s | M (12) | ||
| CGC to CGT (R836R) n2508 Ti | nd | wt | ||
| ACA to AGA (T847R) n2540 Tv | g | Wt |
Frequency as well as mutation type and heredity are shown. Bold characters underline mutations not described elsewhere and italic characters indicate silent point mutations. Nucleotides positions are marked with an n followed by the position number. Transversion or transition mutation types are marked by Tv or Ti respectively. Germline and somatic mutations are designated by g and s respectively and correspond to mutations found (germline, g) or not found (somatic, s, tumor specific) in peripheral blood-DNA of the same patients. KRAS mutations located within the codon 12 (M 12) or 13 (M13) are highlighted.