TABLE II.

Pharmacokinetics of Ceftriaxone in Liver Transplant Recipients

		Patient Number								Mean ± SD
		1	2	3	4	5	6	7	Mean ± SD	Normal Subjects*
I.	Protein Binding
	nP, mM × 104	1.64	3.45	2.47	2.95	1.26	1.04	4.22	2.43 ± 1.19	4.33 ± 0.87
	Ka, mM−1 × 10−4	5.92	1.74	5.90	1.76	1.48	9.83	0.56	3.89 ± 3.40	6.49 ± 1.15
II.	Total Drug
	Cmax, μg/mL	290	218	306	315	245	560	293	318 ± 112	257 ± 17
	C12, μg/mL	61	84	90	33	48	54	117	70 ± 29	46 ± 7
	C24, μg/ml	21	68	81	13	28	19	104	48 ± 36	15 ± 4
	TBC, mL/hr	994	368	311	1706	945	1059	260	806 ± 526	1190 ± 150
	mL/hr/kg	12.0	4.1	4.5	24.4	13.5	16.5	3.3	11.2 ± 7.8
	MRT, hr	12.5	58.8	44.6	8.5	25.8	10.7	48.5	29.9 ± 20.6
	Vss, L	12.4	21.7	13.9	14.5	24.4	11.4	12.6	15.8 ± 5.1
	mL/kg	150	241	201	207	349	178	159	212 ± 68
	Varea, L	13.1	20.9	16.3	14.7	26.7	12.7	12.1	16.6 ± 5.3	10.1 ± 1.0
	mL/kg	158	232	236	210	381	199	153	224 ± 76
	β, hr−1	0.076	0.018	0.019	0.116	0.035	0.083	0.021	0.053 ± 0.039
	t1/2, hr	9.2	39.4	36.3	6.0	19.6	8.3	32.4	13.1b	5.8(4.7–6.8)‡
III.	Unbound Drug
	Cmax, μg/mL	187	70	154	157	178	492	140	197 ± 136
	C12, μg/mL	10	16	11	6	21	11	42	17 ± 12
	C24, μg/mL	2	12	9	2	11	2	37	11 ± 12
	TBC, mL/hr	4322	2318	3085	7163	2245	2980	794	3272 ± 2019	14940 ± 2160
	mL/hr/kg	52.1	25.8	44.7	102.3	32.1	46.6	10.0	44.8 ± 29.1
	MRT, hr	6.6	44.9	25.0	6.2	21.0	4.7	40.7	21.3 ± 16.7
	Vss, L	28.6	104.1	77.2	44.3	47.2	14.0	32.3	49.7 ± 31.0
	mL/kg	345	1156	1119	634	674	218	409	651 ± 368
	Varea, L	38.8	102.7	104.0	54.3	54.0	20.2	31.1	57.9 ± 33.3	162 ± 18
	mL/kg	467	1141	1507	776	771	315	394	767 ± 432
	β, hr−1	0.111	0.023	0.030	0.132	0.042	0.148	0.026	0.073 ± 0.055
	t1/2, hr	6.2	30.7	23.4	5.3	16.7	4.7	27.2	9.5†	7.6

^*Data for total ceftriaxone obtained from ref 6 (Patel); data for unbound ceftriaxone from ref 4.

^†Harmonic mean.

^‡Range in parentheses.