Table 3.
Laboratorial characteristics among cases and controls.
| Cases (n = 39a) | Controls (n = 160a) | Bivariate analysis | |||
|---|---|---|---|---|---|
| Laboratorial characteristics | n (%) | n (%) | p-valuec | OR | CI 95% |
| Lymphopenia prior to first HAART | 0.026b | 2.6 | 1.0-6.5 | ||
| Yes No |
10 (25.6) 19 (48.7) |
22 (13.7) 112 (70) |
|||
| Lymphopenia prior to current HAART | 0.007b | 3.4 | 1.3-8.8 | ||
| Yes No |
10 (25.6) 18 (46.1) |
16 (10) 100 (62.5) |
|||
| CD4-count prior to the first HAARTd (cells/mm3) | 119.2 ± 104.5 Median: 82.5 (IQR: 19-215) | 189.1 ± 87.4 Median: 206 (IQR: 122.7-47.7) |
0.001b | ||
| HIVVL prior to first HAARTd (copies/ml) | 96 251 ± 110 029 Median: 54 193 (IQR: 33 250-117 647) | 263 711 ± 501 872 Median: 104 192 (IQR: 19 766-330 500) | 0.294 | ||
| Logarithm of HIVVL prior to the use of the first HAARTd | 4.7 ± 0.4 Median: 4.7 (IQR: 4.5-5) | 5 ± 0.7 Median: 5.1 (IQR: 4.3-5.5) |
0.547 | ||
| CD4-count prior to the current HAARTd (cells/mm3) | 125.2 ± 109.4 Median: 119 (IQR: 19-190) | 288.2 ± 237.5 Median: 225 (IQR: 164-321) | 0.000b | ||
| HIVVL prior to the current HAARTd (copies/ml) |
90 725 ± 114 158 Median: 54 192 (IQR: 9 360-117 647) | 125 178 ± 168 825 Median: 47 800 (IQR: 16 413-205 773) | 0.487 | ||
| Logarithm of HIVVL prior to the current HAARTd | 4.4 ± 0.9 Median: 4.7 (IQR: 3.9-5) |
4.6 ± 1 Median: 4.8 (IQR: 4.2-5.4) |
0.842 | ||
| Nadir CD4-countd (cells/mm3) | 85.3 ± 68.1 Median: 80.5 (IQR: 19-127.2) | 177.8 ± 87.8 Median: 202 (IQR: 109.5-239.5) |
0.000b | ||
| Time of undetectable HIVVLd (months) | 9.2 ± 4.2 Median: 9.5 (IQR: 5-12.2) | 28.8 ± 21.3 Median: 26.5 (IQR: 12.7-35.7) |
0.000b | ||
| Time of HIVVL below 1,000 copies/mld (months) | 18.8 ± 20.3 Median: 12 (IQR: 8-20.2) | 38.9 ± 25.2 Median: 28 (IQR: 22.2-65.2) |
0.000b | ||
n, number; OR, odds ratio; CI 95%, confidence interval of 95%; HAART, highly active antiretroviral therapy; CD4, CD4 Lymphocyte Count; HIVVL, HIV viral load; Nadir CD4-count, the lowest CD4 ever presented by patient; Undetectable HIVVL, over time the most common limit of detection was less than 400 copies/ml.
a different totals are due to missing data.
b p-value < 0,050.
c Chi-square test or Fisher's exact test were used for comparison of categorical variables between the two groups, as more appropriate. For continuous variables, "Student's" T test was used for comparison of normal distributions between the two groups. For non-normal distributions, it was used the Mann-Whitney test.
d Continuous data are represented by mean ± standard deviation and by median with interquartile range (IQR).