Figure 4.
Arrdc3-deficient mice are resistant to age-induced obesity. (A) Total body mass of littermate wild-type (+/+), heterozygous (+/−), and homozygous (−/−) Arrdc3 knockout mice from 5 to 20 weeks of age. Male n = 10–18, 15–33, 6–11; female n = 9–10, 11–30, 7–14 for +/+, +/−, and −/− genotypes respectively. (B) Perigonadal fat mass expressed as a percentage of total body mass at 5–-7 months of age. Male n = 7, 6, 3; female n = 6, 9, 5. (C) Adiposity of male and female littermates measured by DEXA scanning at 8–12 weeks of age. Male n = 7, 6, 4; female n = 6, 7, 5. Error bars represent mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001 vs. wild-type. See also Figure S4.